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. 2013 Jul 30;8(7):e69187. doi: 10.1371/journal.pone.0069187

Table 4. Non-Embeddability – D1 Human, Rat, Mouse Triad (8394 Alignments).

STEPS a
Edge Codon position 1 2 3 4 5 NEb Matrices NE Processesc
Human 1 0 0 0 0 0 0 0
2 0 0 0 0 0 0 0d
3 16 16 0 3 91 107 6 (5.6)
Mouse 1 0 0 0 0 0 0 0
2 0 0 0 0 0 0 0
3 1 1 0 0 0 1 0
Rat 1 0 0 0 0 0 0 0
2 0 0 0 0 0 0 0
3 0 0 0 0 2 2 0

Inline graphic Steps to identify Non-embeddability 1. Inline graphic, 2. Negative eigenvalues have odd algebraic multiplicity, 3. Complex eigenvalues occur in non-conjugate pairs, 4. The set of eigenvalues, Inline graphic, lie outside the region in the complex plane, 5. Inline graphic – negative off-diagonals – threshold −0.1, Inline graphic NE =  Non-Embeddable, Inline graphic No. rejections of Inline graphic from parametric bootstrap scheme with a p-value Inline graphic (percentage of total tests), Inline graphic 1 Alignment failed to find stable estimates.