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. 2013 Jul 30;8(7):e69209. doi: 10.1371/journal.pone.0069209

Figure 4. Inactivation of Nbn and Atm leads to increase of DSBs and apoptosis in medial ganglionic eminence (MGE).

Figure 4

(A) Accumulation of γ-H2AX foci in MGE of NbnNes-Cre and Nbn/AtmNes-Cre brains at E15.5 (Magnification ×200). (B) Immunohistochemistry indicates stabilization of p53 protein in the E15.5 MGE following Nbn and Atm inactivation (Magnification ×200). (C) Increased apoptosis in the SVZ from E15.5 MGE indicated by cleaved caspase-3 positive cells. Cx: Cortex, MGE: Medial Ganglionic Eminence, VZ:Ventricular Zone, SVZ:Sub ventricular Zone (Magnification ×200).