Table 2. Genes increased or decreased as part of the acute response to radiation.
Rank | Symbol | Gene name | Fold increase | P value | Long-term | Function |
1 | c7 | complement component 7 | 23.58 | <0.0001 | unchanged | complement |
2 | LOC100330542 | Hif3a-like | 21.18 | <0.0001 | up, less | regulation of transcription |
3 | igfbp1b | insulin-like growth factor binding protein 1b | 15.22 | <0.0001 | unchanged | regulation of cell growth |
4 | cpt1b | carnitine palmitoyltransferase 1B (muscle) | 12.70 | <0.0001 | unchanged | lipid metabolism |
5 | glula | glutamine synthase a | 10.12 | <0.0001 | up, less | glutamine biosynthesis |
6 | crb2 | crumbs homolog 2 | 9.42 | 0.0003 | unchanged | brain development |
7 | mknk2b | MAP kinase-interacting serine/threonine kinase 2b | 9.41 | <0.0001 | up, less | regulation of translation |
8 | thraa | thyroid hormone receptor alpha a | 8.69 | <0.0001 | up, less | regulation of transcription |
9 | ucp2 | uncoupling protein 2 | 7.91 | <0.0001 | unchanged | transport |
10 | histh1 | Histone H1 like | 7.42 | <0.0001 | up, less | chromatin component |
Rank | Symbol | Gene name | Fold decrease | P value | Long-term | Function |
1 | hspa5 | heat shock protein 5 | 29.19 | <0.0001 | down, less | response to stress |
2 | cebpa | C/EBP alpha | 13.19 | <0.0001 | down, less | regulation of transcription |
3 | dynll1 | dynein, light chain, LC8-type 1 | 7.31 | <0.0001 | down, less | microtubule-based process |
4 | pdia4 | protein disulfide isomerase associated 4 | 6.21 | <0.0001 | down, less | glycerol ether metabolism |
5 | cask | calcium/calmodulin-dependent serine protein kinase | 5.86 | <0.0001 | down, less | protein phosphorylation |
6 | calrl | calreticulin like | 5.34 | <0.0001 | down, less | protein folding |
7 | prox1/prox2 | prospero-related homeobox gene 1/2 | 5.22 | <0.0001 | down, less | lymphangiogenesis |
8 | ghrb | growth hormone receptor b | 4.91 | <0.0001 | unchanged | hormone receptor |
9 | cpox | coproporphyrinogen oxidase | 4.69 | <0.0001 | down, less | porphyrin biosynthesis |
10 | mlec | malectin | 4.67 | <0.0001 | down, less | protein N-glycosylation |
Top 10 genes that were increased and top 10 genes that were decreased in association with the acute response to radiation, drawn from Table S2. Gene symbols, gene names, fold change, and P values (in the “time comparison”, Fig. 1C) are given. Expression of the genes listed here was either unchanged, or changed less, in the long-term response (as indicated in column labeled “Long-term”). Some gene names and functions have been edited, and some have been omitted, as in Table 1.