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. 2013 Jul 30;8(7):e69445. doi: 10.1371/journal.pone.0069445

Table 2. Genes increased or decreased as part of the acute response to radiation.

Rank Symbol Gene name Fold increase P value Long-term Function
1 c7 complement component 7 23.58 <0.0001 unchanged complement
2 LOC100330542 Hif3a-like 21.18 <0.0001 up, less regulation of transcription
3 igfbp1b insulin-like growth factor binding protein 1b 15.22 <0.0001 unchanged regulation of cell growth
4 cpt1b carnitine palmitoyltransferase 1B (muscle) 12.70 <0.0001 unchanged lipid metabolism
5 glula glutamine synthase a 10.12 <0.0001 up, less glutamine biosynthesis
6 crb2 crumbs homolog 2 9.42 0.0003 unchanged brain development
7 mknk2b MAP kinase-interacting serine/threonine kinase 2b 9.41 <0.0001 up, less regulation of translation
8 thraa thyroid hormone receptor alpha a 8.69 <0.0001 up, less regulation of transcription
9 ucp2 uncoupling protein 2 7.91 <0.0001 unchanged transport
10 histh1 Histone H1 like 7.42 <0.0001 up, less chromatin component
Rank Symbol Gene name Fold decrease P value Long-term Function
1 hspa5 heat shock protein 5 29.19 <0.0001 down, less response to stress
2 cebpa C/EBP alpha 13.19 <0.0001 down, less regulation of transcription
3 dynll1 dynein, light chain, LC8-type 1 7.31 <0.0001 down, less microtubule-based process
4 pdia4 protein disulfide isomerase associated 4 6.21 <0.0001 down, less glycerol ether metabolism
5 cask calcium/calmodulin-dependent serine protein kinase 5.86 <0.0001 down, less protein phosphorylation
6 calrl calreticulin like 5.34 <0.0001 down, less protein folding
7 prox1/prox2 prospero-related homeobox gene 1/2 5.22 <0.0001 down, less lymphangiogenesis
8 ghrb growth hormone receptor b 4.91 <0.0001 unchanged hormone receptor
9 cpox coproporphyrinogen oxidase 4.69 <0.0001 down, less porphyrin biosynthesis
10 mlec malectin 4.67 <0.0001 down, less protein N-glycosylation

Top 10 genes that were increased and top 10 genes that were decreased in association with the acute response to radiation, drawn from Table S2. Gene symbols, gene names, fold change, and P values (in the “time comparison”, Fig. 1C) are given. Expression of the genes listed here was either unchanged, or changed less, in the long-term response (as indicated in column labeled “Long-term”). Some gene names and functions have been edited, and some have been omitted, as in Table 1.