Figure 3. N3 conferred protection on 5746-preinfected hSCARB2-transgenic mice.
(A) and (B) 7-day day old hSCARB2-transgenic mice (n = 9–10/group) were preinfected with a lethal dose of EV71 5746 virus at 1×105 pfu. After 3 h of infection, 200 µg of N3 or isotype antibody was injected i.p. Mice without any antibody treatment were included. The Experiments were repeated twice, and 100× magnification of pictures (A) shown the representative data were taken. The graph represents the scoring of paralysis (B) from each group of mice. The scores were monitored on a daily basis. One-way ANOVA and the Kruskal-Wallis test were used for statistical analysis (*p< = 0.05, **p< = 0.01).