Figure 5. N3 reduced the pathogenesis of EV71 in the limb muscles and in the intestinal mucosa and villi.

(A) Brainstem and (B) limb muscle tissues were isolated from the 1×10⁵ pfu of 5746-infected 7-day old hSCARB2-Tg mice which treated i.p. with 200 µg of N3 or isotype antibodies (3 h post infection), and from antibody-untreated mice staining with anti-EV71 antibody on Day 4 post infection. The normal tissues (MOCK) with anti-EV71 staining were also prepared. (C) H/E staining of intestine (>8 days post infection) from the groups of mice described in (A) was shown. Observations were made at a magnification of x200 for (A) and x100 for (B) and (C).