Figure 2. Influence of viral genetic diversity on hepatitis B viral load by HBV subgenotypes.

The plot show the estimated impact (β estimates; regression coefficients) per 1-unit increment of dS (10⁻³ substitution per site), dN (10⁻³ substitution per site), or genetic distance (10⁻² nucleotide substitution) on cross-sectional (solid circle and horizontal line) and longitudinal (empty circle and horizontal line) measures of viral load (log copies/mL) and 95% confidence intervals (CIs). All regression models include age as a covariate. The partial R² values measure the marginal contribution of each parameter of viral genetic diversity to the variability in baseline viral load when age was already in the respective linear regression model.