Figure 2. Circadian deficits in locomotor activity in Q175 mutant mice at 9 months of age.

A. Representative double plotted actograms of wheel running activity from age-matched WT (left), Q175 Het (middle) and Q175 Hom (right) mice under 12∶12 light:dark (LD) and constant darkness (DD) are shown. The white/black bars on top indicate the LD cycle, and gray shading indicates darkness. Successive days of activity are plotted from top to bottom. B. Chi-square (χ²) periodograms of 10 days of activity in DD are shown from the three genotypes at 9 months, with the peak of the periodogram indicating the free-running period of each mouse. Power (%V) refers to the normalized amplitude of the periodogram. The intersecting diagonal line indicates significance to P<0.05.