Table 2. Two way repeated measures ANOVA were used to determine the effects of age and genotype in the same cohort of mice from 3 to 12 months, and we report the F and P statistics for the comparisons reported in Fig. 4 and 5 in this table.

		Two way repeated measures ANOVA
		Age		Genotype		Interactions
		F	P	F	P	F	P
LD	Nocturnality	6.01	0.001	1.52	0.242	1.74	0.126
	Power (%V)	110.65	<0.001	8.06	0.002	8.04	<0.001
	Activity (rev/hr)	141.72	<0.001	11.26	<0.001	4.79	<0.001
	Alpha, α (min)	7.44	<0.001	3.72	0.041	0.89	0.511
	Fragmentation (bouts/day)	22.15	<0.001	3.19	0.062	3.58	0.004
	Precision (min)	5.52	0.002	6.24	0.007	2.60	0.026
DD	Tau, τ (hr)	4.61	0.006	0.83	0.451	1.13	0.355
	Power (%)	76.03	<0.001	2.17	0.139	6.51	<0.001
	Activity (rev/hr)	77.04	<0.001	13.99	<0.001	4.96	<0.001
	Alpha, α (min)	4.93	0.004	12.06	<0.001	12.19	<0.001
	Fragmentation (bouts/day)	5.86	0.001	9.21	0.001	7.95	<0.001
	Precision (min)	8.15	<0.001	11.60	<0.001	6.69	<0.001

Sample sizes are as reported in Table 1 .