Table 1. Overlapping decreased expression changes relative to control induced by SRC-2 KD and cAMP in MCF-7 cells.
Signal intensity | FC | ||||||
Gene | Definition | SRC-2 shRNA | cAMP | CtrshRNA | SRC-2 shRNA/Ctr shRNA | cAMP/Ctr shRNA | |
AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 255 | 257 | 507 | −1.98 | −1.98 | |
ARHGEF19 | Rho guanine nucleotide exchange factor (GEF) 19 | 420 | 415 | 632 | −1.50 | −1.53 | |
BCL11B | B-cell CLL/lymphoma 11B (zinc finger protein),transcript variant 1 | 232 | 313 | 570 | −2.46 | −1.83 | |
CAV1 | caveolin 1, caveolae protein, 22kDa | 3534 | 2946 | 5595 | −1.59 | −1.91 | |
EGR1 | early growth response 1 | 1159 | 1125 | 1799 | −1.55 | −1.62 | |
KLK5 | kallikrein-related peptidase 5, transcript variant 1 | 345 | 292 | 598 | −1.74 | −2.06 | |
KLK5 | kallikrein-related peptidase 5, transcript variant 2 | 244 | 226 | 416 | −1.72 | −1.84 | |
KRT1 | keratin 1 (epidermolytic hyperkeratosis) | 143 | 118 | 229 | −1.60 | −1.94 | |
KRT5 | keratin 5 | 171 | 197 | 347 | −2.03 | −1.76 | |
KRTDAP | keratinocyte differentiation-associated protein | 173 | 283 | 571 | −3.29 | −2.02 | |
Protein S100-A9 | S100 calcium binding protein A9 (calgranulin B) | 308 | 644 | 1345 | −4.37 | −2.11 | |
Protein S100-A8 | S100 calcium binding protein A8 | 242 | 530 | 1892 | −7.82 | −3.58 | |
TAGLN | transgelin, transcript variant 2 | 257 | 350 | 797 | −3.10 | −2.28 |
Genes with FC ≥1.5 and q-value = 0 are shown in addition to their respective expression signals in the three microarray samples. cAMP, short-hairpin control MCF-7 cells treated with cAMP analogue (8-CPT-cAMP) and cAMP-elevating agents (IBMX and forskolin).