Scheme 5. Preparation of the 2-Guanidinylglucose-6-phosphate Coenzyme Candidate (49).
a) TES-Cl, DIEA, DMF, 70°C; b) cat. PPTS, DCM, MeOH; c) POCl3/py, then H2O, DMF/AcOH followed by 1 N HCl.
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