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Schematic representation of SH2B1 sequence (gray segment).
“x” symbols in the protein sequence represents amino acid sites that do not share identity across homologous species. The recognized domains and the fully conserved amino acid region 451-490 are highlighted (black segments). Amino acids sequence 451-490 is shown in one-letter code, the putative SH3-binding motif PELPPR segment (aa 470-475) is greyed and the site of mutation Ala484 is underscored.
