Table 3.
Association between rs4788102 and MI in the three study samples
| Study samples | SH2B1 rs4788102 genotype | OR (95% CI) | p | |||
|---|---|---|---|---|---|---|
| GG | GA | AA | Additive model | |||
| GHS | Patients without MI (n=550) | 282 (51.3%) | 218 (39.6%) | 50 (9.1%) | ||
| 1.42 (1.12-1.81) | 0.004 | |||||
| 1.44 (1.11-1.86) | 0.006a | |||||
| 1.38 (1.05-1.81) | 0.02b | |||||
| Patients with MI (n=190) | 80 (42.1%) | 79 (41.6%) | 31 (16.3%) | |||
|
| ||||||
| JHS | Patients without MI (n=637) | 282 (44.3%) | 277 (43.5%) | 78 (12.2%) | ||
| 1.11 (0.87-1.41) | 0.39 | |||||
| 1.15 (0.90-1.47) | 0.28a | |||||
| 1.16 (0.89-1.51) | 0.26b | |||||
| Patients with MI (n=181) | 73 (40.3%) | 84 (46.4%) | 24 (13.3%) | |||
|
| ||||||
| CZ | Patients without MI (n=356) | 187 (52.5%) | 140 (39.3%) | 29 (8.1%) | ||
| 1.02 (0.72-1.44) | 0.91 | |||||
| 1.00 (0.70-1.44) | 0.98a | |||||
| 1.00 (0.58-1.73) | 0.99b | |||||
| Patients with MI (n=101) | 51 (50.5%) | 43 (42.6%) | 7 (6.9%) | |||
|
| ||||||
| Pooledc | Patients without MI (n=1543) | 751 (48.7%) | 635 (41.1%) | 157 (10.2%) | ||
| 1.21 (1.04-1.41) | 0.016 | |||||
| 1.21 (1.04-1.42) | 0.016 a | |||||
| 1.24 (1.04-1.47) | 0.018b | |||||
| Patients with MI (n=472) | 204 (43.2%) | 206 (43.6%) | 62 (13.1%) | |||
GHS=Gargano Heart Study; JHS=Joslin Heart Study; CZ= Catanzaro.
a
Adjusted for sex, age and smoking habit;
b
adjusted for BMI, sex, age, smoking habit, glycosylated haemoglobin, HDL cholesterol and triglycerides levels.
c
Data were analyzed after adjusting for “study sample”.