Figure 3.

Effects of aging on NMDAR-LTP and VGCC-LTP. A, LTP induced with TBS (arrowhead) is blocked by 100 μm APV. B, LTP induced with a 200 Hz tetanus (arrowhead) is modestly reduced by 100 μm APV and completely blocked by the further addition of the L-type Ca⁺² channel blocker nifedipine (10 μm). C, NMDAR-LTP is similar in the three groups. D, VGCC-LTP is modestly reduced in AI, but not in AU rats. E, Distributions of the NMDAR-LTP magnitude computed by pooling all the slices in Y, AI, and AU rats. F, Similarly, distributions of the non-NMDAR-LTP for the three age groups. Young, ○; AU, black triangles; AI, gray triangles. The number of slices and rats is indicated in parentheses in each part. Traces on C and D: average of 10 consecutive responses recorded before (thick line) and 60 min after conditioning (thin line).