Figure 7.

Y₁ receptors regulate the stress-induced change in adrenal secretory capacity. A, Example of amperometric events evoked by a 5 Hz train of 200 voltage-clamp depolarizations from chromaffin cells from BIBP 3226-injected control and stressed mice. B, Cumulative amplitude distribution of amperometric events from control (Ctrl) and stressed BIBP 3226-injected wild-type animals (control, 1867 events; FST, 2223 events; n = 20 cells per condition). C, Secretory event number and amplitude of voltage-dependent calcium current from BIBP 3226-injected control and experimental animals (mean ± SEM, n = 3 paired experiments, 6–7 cells per treatment in each experiment). D, The same protocol as in A was used to evoke amperometric events from chromaffin cells from saline-injected control and stressed animals. E, Cumulative amplitude distribution of amperometric events shows a significant rightward shift from saline-injected, stressed animals (control, 1809 events; FST, 2040 events; n = 20 cells per condition). *p < 0.01. F, Secretory event number and amplitude of voltage-dependent calcium current from saline-injected control and experimental animals (mean ± SEM, n = 3 paired experiments, 6–7 cells per treatment in each experiment).