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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Clin Exp Allergy. 2013 Aug;43(8):902–913. doi: 10.1111/cea.12146

Figure 4. Elevated LTC4S mRNA levels define a subpopulation of EoE patients with a distinct inflammatory transcriptome.

Figure 4

(A) A subpopulation of 23 EoE biopsies with high LTC4S mRNA counts was defined (High) using a cutoff of the mean + 2 standard deviations from the LTC4S mRNA expression in all control biopsies. 31 EoE biopsies (64%) had expression below the cutoff and were classified as low LTC4S expression (Low). GAPDH expression was similar between LTC4SHIGH and LTC4SLOW groups. (B) IGHE mRNA transcripts were similar between LTC4SHIGH and LTC4SLOW groups. (C) LTC4SHIGH and LTC4SLOW samples did not differ significantly in expression of the EoE marker genes eotaxin-3, periostin or IL-13. (D) LTC4SHIGH biopsies had significantly higher mRNA levels of TSLP (p=0.009) and CD4 (p=0.01). (E) Conversely, mRNA levels of IL-23 were significantly lower (p=0.04) in LTC4SHIGH compared to LTC4SLOW biopsies. When compared to control biopsies, IL-23 mRNA was higher in biopsies of patients with RE compared to normal controls (p<0.001). IL-23 expression in LTC4SHIGH was not different from normal controls and LTC4SLOW biopsies had IL-23 expression similar to RE patients. *p<0.05, **p<0.01, ***p<0.001, NS: not significant.