Figure 3. Schematic of central metabolism of Methylophilaceae and major metabolic modules addressed in this study.

As the role of MCC remains unknown, dashed lines indicate potential scenarios for its intermediates originating from central metabolic pathways or from external sources. Modules common to all three organisms indicated in red. Modules not shared by all three organisms are shown in black. See Table S11 for details. MDH, methanol dehydrogenase; MADH, methylamine dehydrogenase; NMGP, N-methylglutamate pathway; H4MPT, tetrahydromethanopterin-linked pathway for formaldehyde oxidation; RuMP, ribolemonophosphate pathway; FDH1,2, formate dehydrogenase enzymes; GndA,B, 6-phosphagluconate dehydrogenase enzymes; MCC, methylcitric acid cycle.