Table 2.
Sequence polymorphisms for P. vivax Duffy binding protein region from multiple clones obtained from human peripheral blood samples (three examples) at select amino acid residues*
| AA codon | 308 | 333 | 371 | 375 | 384 | 385 | 386 | 390 | 417 | 424 | 437 | 447 | 503 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||||
| Bleed code .clone | AGG (R) | CTT (L) | AAA (K) | AAT (N) | GAT (D) | GAA (E) | AAG (K) | CGT (R) | AAT (N) | TTA (L) | TGG (W) | TCA (S) | ATA (I) |
| 200.1 | … | … | … | … | … | … | … | … | … | … | … | … | … |
| . | . | . | . | . | . | . | . | . | . | . | . | . | |
| 200.2(8)† | ..T | … | … | … | .G. | … | … | .A. | … | A.. | … | AA. | … |
| (S) | . | . | . | (G) | . | . | (H) | . | (I) | . | (K) | . | |
| 200.7 | ..T | … | … | … | .G. | … | C.. | … | ..A | A.. | C.. | … | .A. |
| (S) | . | . | . | (G) | . | (Q) | . | (K) | (I) | (R) | . | (K) | |
| 1066.1 (2) | ..T | … | G.. | … | .G. | … | C.. | … | ..A | A.. | C.. | … | … |
| (S) | . | (E) | . | (G) | . | (Q) | . | (K) | (I) | (R) | . | . | |
| 1066.2 (3) | ..T | … | G.. | … | .G. | … | C.. | … | ..A | A.. | C.. | … | .A. |
| (S) | . | (E) | . | (G) | . | (Q) | . | (K) | (I) | (R) | . | (K) | |
| 1066.6 | … | … | … | … | … | … | … | … | … | … | … | … | .A. |
| . | . | . | . | . | . | . | . | . | . | . | . | (K) | |
| 1066.7 (2) | … | … | … | … | … | … … | … | … | … | … | … | … | … |
| . | . | . | . | . | . | . | . | . | . | . | . | . | |
| 1488.1 (10) | ..T | … | … | … | .G. | … | … | .A. | … | A.. | … | AA. | … |
| (S) | . | . | . | (G) | . | . | (H) | . | (I) | . | (K) | . | |
*
Positions 235–521 were sequenced; the sequences shown are either those in which mutations are present in at least two cloned samples or that had been identified previously.7–9,18 GenBank accession numbers are as follows: AF469541–AF469557, AF469593–AF469602, AY970837–AY970848, AY970878–AY970897, AY970918–AY970925.
†
Parentheses show the number of clones with the same PvDBP haplotype at the select amino acid residues.