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. 2013 Jul 8;1(2):e00015. doi: 10.1002/phy2.15

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© 2013 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Experiment 2: leptin (A) and insulin (B) concentrations were significantly increased in all HFD groups, but those with heterotransplantations. Heterotransplantation restored insulin and leptin levels to chow control levels, whereas removal of subcutaneous adipose tissue induced increases greater than HFD control mice. Although hepatic insulin sensitivity was decreased by HFD, heterotransplantation in HFD mice restored hepatic insulin sensitivity to chow controls levels (C). Subcutaneous fat removal in HFD-fed mice did not change hepatic insulin sensitivity. Different letters indicate significance P ≤ 0.05.