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. 2013 Jul;3(7):130019. doi: 10.1098/rsob.130019

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© 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 8. — Model for checkpoint-dependent regulation of DSB formation. (a) DSB formation triggers Mec1/Tel1-dependent positive and negative feedback loops, which modulate the rate of DSB formation. The Rad24/Mec1-dependent positive stimulation of DSB formation is activated by ssDNA formation, leading to transient Ndt80 inactivation, and is required to overcome defects in DSB formation (i.e. spo11-HA and spo11-D290A backgrounds). Negative regulation of DSB formation is mediated by both Tel1 and Ndt80. (b) Cartoon to describe the relative changes in rate of DSB formation over time in meiotic prophase for various mutants (see text for details).