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. 2013 Jul;3(7):130061. doi: 10.1098/rsob.130061

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© 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 1. — Potential function of MTs in nucleokinesis. (a) The dynein-dependent nucleokinesis model. In migrating neurons, the centrosome is positioned in front of the nucleus (N–C coupling). Cytoplasmic MTs derived from the centrosome surround the nucleus, and after the leading process elongates, the centrosome uncouples from the nucleus and advances into the leading process. Saltatory forward movement of the nucleus occurs using a minus-end-directed dynein motor along cytoplasmic MTs. (b) Occasionally, nucleokinesis occurs prior to centrosome movement, inverting the relative position of the centrosome and nucleus (N–C inversion). Centrosome positioning in front of the nucleus is then recaptured. This type of nucleokinesis cannot be explained by dynein-dependent pulling of the nucleus along cytoplasmic MTs. Small black arrows within the cells indicate the moving direction of centrosome or nucleus.