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. 2013 Jul 18;9(7):680–692. doi: 10.7150/ijbs.6623

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Fig 5 — CD44v3 is a novel target of miRNA-143. (A) The putative target genes and mutant complementary sequences of the CD44v3 mRNA 3'-UTR are shown with the miR-143 sequence. (B) The luciferase activities of five putative target gene reporter vectors cotransfected with P-miR-143 or Pc3.1 were measured by dual luciferase assay (*P < 0.05). (C) The luciferase activities of the wild type CD44v3 3'-UTR (Wt) and mutant type CD44v3 3'-UTR (Mut) cotransfected with P-miR-143 or Pc3.1 were measured by dual luciferase assay (*P < 0.05). (D) The expression level of CD44v3 mRNA in A549 transfected with P-miR-143 or Pc3.1 was determined by the qRT-PCR assay (*P < 0.05). (E) The expression level of CD44v3 protein in A549 transfected with P-miR-143 or Pc3.1 was determined by western blot assay.