Table 2.
Biological Factors and Symptom Measures Overall and by Perceived Pain
| Overall (n=32) | Perceived Pain grouping | Pain interference grouping | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Without perceived pain (n=12) | With perceived pain (n=20) | Without pain interference (n=15) | With pain interference (n=17) | |||||||
| Mean (std dev) | Median | Mean (std dev) | Median | Mean (std dev) | Median | Mean (std dev) | Median | Mean (std dev) | Median | |
| Age | 47.66 (7.68) | 49.50 | 45.58 (7.54) | 46.00 | 48.90 (7.68) | 50.00 | 46.60 (7.94) | 47.00 | 48.44 (7.79) | 50.00 |
| Symptoms (range) | ||||||||||
| Anxiety (0–12) | 6.25 (3.93) | 6.0 | 6.00 (4.94) | 4.5 | 6.40 (3.32) | 6.5 | 5.20 (4.25) | 3.0 | 7.63 (3.05)* | 7.5 |
| Depression (0–10) | 3.26 (3.12) | 2.0 | 1.67 (2.74) | 0.0 | 4.26 (2.98)* | 3. 0 | 1.33 (1.80) | 1.0 | 5.33 (2.94)* | 6.0 |
| Fatigue (0–9) | 6.8 (1.46) | 6.0 | 5.7 (1.84) | 0.0 | 7.35 (1.97) | 6.9 | 5.14 (1.26) | 5.0 | 8.12 (2.55)* | 8.5 |
| Sleep disturbance (0–65) | 44.81 (18.71) | 44.0 | 36.58 (12.46) | 32.5 | 50.0 (20.37)* | 45.0 | 33.21 (12.56) | 32.5 | 54.19 (18.28)* | 56.0 |
| Pain severity (0–6) | 1.72 (1.40) | 3.0 | 0.0 | 0.0 | 2.9 (1.65)* | 3.0 | 0.55 (1.86) | 0.0 | 3.29 (1.65)* | 3.0 |
| Pain interference (0–5) | 1.34 (2.10) | 0.14 | 0.0 | 0.0 | 2.17 (2.34)* | 1.14 | 0.0 | 0.0 | 2.03 (1.09)* | 1.48 |
| Biological Factors | ||||||||||
| IL1β (pg/mL) | 188.08 (369.18) | 65.00 | 106.04 (80.31) | 77.25 | 237.30 (460.26) | 65.00 | 96.20 (74.29) | 64.50 | 263.34 (509.93) | 63.25 |
| IL2 (pg/mL) | 321.09 (500.31) | 144.50 | 293.67 (323.11) | 214.75 | 337.55 (589.24) | 113.50 | 267.37 (294.37) | 208.50 | 346.03 (649.49) | 99.00 |
| IL4 (pg/mL) | 490.39 (113.60) | 503.25 | 456.96 (79.05) | 462.00 | 510.45 (127.70) | 518.75 | 476.00 (80.35) | 481.50 | 502.59 (142.30) | 515.00 |
| IL5 (pg/mL) | 36.78 (37.85) | 26.50 | 46.88 (59.84) | 24.50 | 30.73 (12.70) | 28.00 | 42.47 (53.90) | 23.00 | 31.81 (13.72) | 28.00 |
| IL6 (pg/mL) | 289.94 (505.34) | 134.00 | 188.00 (163.41) | 134.00 | 351.10 (625.06) | 133.00 | 177.37 (147.93) | 130.00 | 389.66 (695.33) | 129.50 |
| IL7 (pg/mL) | 123.80 (124.85) | 90.75 | 85.71 (30.15) | 87.25 | 146.65 (153.10)* | 94.25 | 85.03 (27.30) | 86.00 | 154.56 (168.74)* | 93.25 |
| IL8 (pg/mL) | 647.31 (989.42) | 232.50 | 758.46 (1244.11) | 239.25 | 580.63 (829.84) | 232.50 | 655.33 (1123.59) | 230.00 | 642.91 (919.03) | 232.00 |
| IL10 (pg/mL) | 231.98 (378.00) | 122.00 | 148.83 (81.99) | 115.25 | 281.88 (471.43) | 122.00 | 142.57 (73.87) | 115.50 | 306.25 (524.17) | 122.50 |
| IL12 (pg/mL) | 188.08 (420.86) | 88.25 | 288.21 (669.43) | 86.75 | 128.00 (139.33) | 89.25 | 247.07 (599.51) | 84.50 | 137.59 (154.96) | 90.00 |
| IL13 (pg/mL) | 56.16 (37.23) | 47.50 | 44.54 (9.95) | 40.50 | 63.13 (45.48) | 49.00 | 45.13 (9.01) | 43.50 | 65.28 (50.54)* | 50.00 |
| IL17 (pg/mL) | 167.30 (27.14) | 166.25 | 162.42 (35.35) | 158.25 | 170.23 (21.32) | 175.50 | 162.70 (32.11) | 160.50 | 171.13 (22.80) | 177.00 |
| GMCSF (pg/mL) | 335.25 (375.59) | 225.50 | 251.71 (113.42) | 219.00 | 385.38 (464.40) | 225.50 | 241.17 (107.60) | 223.00 | 400.75 (508.44) | 224.75 |
| IFNγ (pg/mL) | 110.08 (250.70) | 38.00 | 48.08 (26.79) | 37.50 | 147.28 (313.44) | 38.00 | 45.47 (24.40) | 37.00 | 170.56 (348.22) | 38.50 |
| TNFα (pg/mL) | 209.17 (194.20) | 177.75 | 164.21 (61.04) | 150.00 | 236.15 (239.44) | 183.00 | 166.80 (55.05) | 163.00 | 255.66 (265.01) | 183.75 |
| CRP (mg/L) | 4728.57 (4849.53) | 2219.73 | 2841.29 (4461.45) | 1046.50 | 5860.94 (4821.65)* | 3820.5 | 3421.44 (4838.23) | 1391.63 | 6130.24 (4735.14)* | 5123.88 |
GM-CSF=granulocyte-macrophage colony-stimulating factor, IFN-γ = interferon gamma, TNF-α = tumor necrosis factor alpha Anxiety subscale range from 0–21; Depression subscale range from 0–21; Fatigue scale range from 0–10; Sleep disturbance scale range from 0–147; Pain severity scale range from 0–10; Pain interference scale range from 0–10.
significant differences for perceived pain groupings: IL-7 p< 0.02, IL-13 p<0.02, CRP p<0.01; depression p<0.01, sleep disturbances p<0.01, pain interference p<0.01.
significant differences for pain interference groupings: IL-7 p<0.02, IL-13 p<0.04, CRP p<0.03, anxiety p<0.03, depression p< 0.001, fatigue p<0.02, sleep disturbances p<0.001, pain p<0.0003.