Table 3.
Biological Factors and Symptom Measurements by Treatment Type
| Lumpectomy | Median | Mastectomy | Median | Breast biopsy | Median | P-values | Lump vs mastectomy | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | All 3 treatments | |||||
|
| |||||||||||
| Age (rounded) | 43.6 | 8.7 | 47.0 | 48.7 | 7.5 | 50.0 | 49.5 | 5.9 | 51.5 | 0.29 | 0.15 |
| Symptoms | |||||||||||
| Anxiety | 4.0 | 2.9 | 3.0 | 6.7 | 3.9 | 7.0 | 8.0 | 4.8 | 8.0 | 0.19 | 0.1 |
| Depression* | 1.0 | 1.8 | 0.0 | 3.4 | 2.9 | 2.50 | 6.8 | 3.0 | 7.0 | 0.01* | 0.01* |
| Fatigue | 4.3 | 2.7 | 0.0 | 6.8 | 1.9 | 3.50 | 8.7 | 1.7 | 8.5 | 0.10 | 0.06 |
| Sleep | 38.1 | 10.6 | 36.0 | 45.6 | 21.1 | 44.5 | 52.8 | 16.3 | 49.0 | 0.45 | 0.38 |
| Perceived pain* | 0.3 | 0.8 | 0.0 | 2.0 | 2.2 | 3.0 | 3.0 | 1.3 | 2.5 | 0.07 | 0.03* |
| Pain interference* | 0.0 | 0.1 | 0.0 | 1.6 | 2.3 | 0.3 | 2.6 | 2.3 | 2.4 | 0.04* | 0.01* |
| Biological Factors | |||||||||||
| IL1β (pg/mL) | 104.6 | 59.8 | 95.5 | 164.3 | 313.2 | 59.0 | 459.1 | 793.3 | 67.8 | 0.51 | 0.18 |
| IL2 (pg/mL) | 353.8 | 386.1 | 281.0 | 301.3 | 545.4 | 119.0 | 367.9 | 545.0 | 113.8 | 0.68 | 0.21 |
| IL4 (pg/mL) | 455.9 | 80.4 | 470.0 | 484.6 | 116.9 | 511.0 | 581.0 | 124.0 | 569.8 | 0.20 | 0.55 |
| IL5 (pg/mL) | 57.8 | 76.4 | 32.0 | 29.4 | 12.0 | 27.0 | 38.9 | 27.4 | 25.5 | 0.86 | 0.30 |
| IL6 (pg/mL) | 212.9 | 143.9 | 194.0 | 282.1 | 588.8 | 111.0 | 466.3 | 479.8 | 294.5 | 0.19 | 0.16 |
| IL7 (pg/mL) | 99.6 | 36.0 | 88.5 | 106.5 | 77.5 | 90.0 | 257.1 | 302.1 | 112.5 | 0.06* | 0.82 |
| IL8 (pg/mL) | 224.7 | 64.0 | 191.0 | 718.1 | 1052.7 | 230.0 | 1015.4 | 1444.8 | 311.5 | 0.13 | 0.12 |
| IL10 (pg/mL) | 155.4 | 84.0 | 122.0 | 234.1 | 441.8 | 115.5 | 354.8 | 357.0 | 211.5 | 0.32 | 0.32 |
| IL12 (pg/mL) | 127.5 | 88.2 | 90.0 | 198.4 | 506.6 | 84.5 | 240.1 | 301.1 | 97.5 | 0.51 | 0.44 |
| IL13 (pg/mL) | 48.9 | 15.6 | 41.0 | 51.0 | 17.0 | 47.0 | 95.8 | 97.5 | 49.0 | 0.54 | 0.26 |
| IL17 (pg/mL) | 170.4 | 37.3 | 160.5 | 166.7 | 24.6 | 175.0 | 164.9 | 27.5 | 155.0 | 0.94 | 0.44 |
| GMCSF (pg/mL) | 263.1 | 88.0 | 241.0 | 308.8 | 332.0 | 197.0 | 600.1 | 772.6 | 236.5 | 0.62 | 0.23 |
| IFNγ (pg/mL) | 40.8 | 13.5 | 36.5 | 99.5 | 226.3 | 38.0 | 287.0 | 504.0 | 37.0 | 0.50 | 0.13 |
| TNFα (pg/mL) | 142.6 | 40.7 | 136.0 | 183.1 | 59.4 | 178.0 | 462.4 | 52.2 | 221.5 | 0.07* | 0.07* |
| CRP (mg/L) | 1798.6 | 2064.2 | 1214.4 | 5026.3 | 4962.9 | 2224.3 | 8292.8 | 5718.7 | 8619.2 | 0.08 | 0.06 |
GM-CSF=granulocyte-macrophage colony-stimulating factor; IFN-γ = interferon gamma; TNF-α = tumor necrosis factor alpha