Table 3. Susceptibility profile of the clinical NDM-1 producers and their respective transconjugants.
| Antibiotic minimum inhibitory concentration (mg/l) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Isolate | ||||||||||||||
|
IMP |
MEM |
ETP |
CXM |
CTX |
CAZ |
GEN |
AMK |
TET |
TGC |
CIP |
CHL |
COL |
PMB |
|
| Klebsiella pneumoniae | ||||||||||||||
| 547 | 16 | 4 | 12 | > 256 | > 256 | > 256 | 128 | 4 | 32 | 0.25 | 2 | 512 | 0.25 | 3 |
| 547T | > 32 | 1.5 | 1 | > 256 | > 256 | > 256 | 0.064 | 4 | 8 | 0.064 | 1 | 32 | 0.064 | 0.5 |
| 594 | > 32 | 12 | > 32 | > 256 | > 256 | > 256 | 128 | 4 | 32 | 0.25 | 2 | > 256 | 0.5 | 1.5 |
| 594T | > 32 | 12 | 4 | > 256 | > 256 | > 256 | 0.064 | 1 | 0.75 | 0.14 | 0.004 | 3 | 0.125 | 0.75 |
| 693 | > 32 | 12 | 6 | > 256 | > 256 | > 256 | > 256 | 4 | 96 | 0.25 | 0.047 | > 256 | 0.064 | 0.25 |
| 693T | > 32 | 12 | 6 | > 256 | > 256 | > 256 | 0.125 | 1 | 0.05 | 0.047 | 0.002 | 4 | 0.25 | 0.38 |
| 509 | > 32 | > 32 | > 32 | > 256 | > 256 | > 256 | 64 | 8 | > 256 | 0.14 | > 32 | > 256 | 0.38 | 1.5 |
| 509T | > 32 | > 32 | 8 | > 256 | > 256 | > 256 | 0.19 | 1 | 0.25 | 0.125 | 0.008 | > 256 | 0.094 | 0.38 |
| 380 | > 32 | 32 | 32 | > 256 | > 256 | > 256 | > 256 | 16 | 64 | 2 | > 32 | > 256 | 0.25 | 0.5 |
| 380T | > 32 | 32 | 6 | > 256 | > 256 | > 256 | 0.19 | 1 | 0.38 | 0.125 | 0.008 | > 256 | 0.094 | 0.38 |
| 205 | > 32 | > 32 | > 32 | > 256 | > 256 | > 256 | 256 | 2 | 2 | 0.75 | > 32 | > 256 | 0.25 | 0.5 |
| 205T | > 32 | > 32 | 6 | > 256 | > 256 | > 256 | 0.19 | 1 | 0.38 | 0.125 | 0.008 | > 256 | 0.094 | 0.5 |
| Escherichia coli | ||||||||||||||
| 424 | > 32 | 4 | 12 | > 256 | > 256 | > 256 | 1.5 | 8 | 32 | 0.064 | > 32 | 512 | 1.25 | 2 |
| 424T | > 32 | 2 | 8 | > 256 | > 256 | > 256 | 0.125 | 8 | 8 | 0.064 | 1 | 32 | 0.125 | 0.38 |
| 510 | > 32 | > 32 | 12 | > 256 | > 256 | > 256 | > 256 | > 256 | 1 | 0.064 | 32 | 4 | 0.75 | 1 |
| 510T | 4 | 2 | 12 | > 256 | > 256 | > 256 | > 256 | > 256 | 2 | 0.094 | 32 | 12 | 0.047 | 0.25 |
| N12 | > 32 | > 32 | 32 | > 256 | > 256 | > 256 | 1 | 2 | 32 | 0.094 | 32 | 2 | 0.25 | 1.5 |
| N12T | > 32 | > 32 | 4 | > 256 | > 256 | > 256 | 0.25 | 1 | 32 | 0.094 | 0.004 | 1.5 | 0.125 | 0.012 |
| 722 | > 32 | > 32 | > 32 | > 256 | > 256 | > 256 | 1.5 | 4 | 24 | 0.094 | 32 | 2 | 1 | 0.5 |
| 722T | > 32 | 16 | 8 | > 256 | > 256 | > 256 | 0.5 | 2 | 1.5 | 0.023 | 0.004 | 2 | 0.125 | 0.125 |
| Enterobacter cloacae | ||||||||||||||
| 459 | 24 | 16 | 32 | > 256 | > 256 | > 256 | 64 | 6 | > 256 | 0.5 | 12 | 16 | 4 | 16 |
| 459T | > 32 | 3 | 8 | > 256 | > 256 | > 256 | 0.125 | 4 | 8 | 0.064 | 1 | 32 | 0.38 | 0.75 |
| 241 | > 32 | > 32 | > 32 | > 256 | > 256 | > 256 | > 256 | > 256 | 4 | 1 | > 32 | 12 | 1 | 2 |
| 241T | > 32 | 0.5 | 0.2 | > 256 | > 256 | > 256 | > 256 | > 256 | 0.5 | 0.064 | 0.004 | 8 | 0.38 | 0.5 |
| Escherichia coli J53 | 0.125 | 0.016 | 0.04 | 0.38 | 1 | 0.064 | 0.19 | 1 | 0.18 | 0.064 | 0.003 | 2 | 0.125 | 0.38 |
Note: AMK – amikacin; CAZ – ceftazadime; CHL – chloramphenicol; CIP – ciprofloxacin; COL – colistin; CTX – cefotaxime; CXM – cefuroxime; ETP – ertapenem; GEN – gentamicin; IMP – imipenem; MEM – meropenem; PMB – polymyxin B; T – transconjugant; TET – tetracycline; and TGC – tigecycline.