Table I.
Most advanced methods for pathogen reduction of labile blood products.
| Photosensitiser + light source | Blood product | Kill power rate | |
|---|---|---|---|
| INTERCEPT Blood System | amotosalen-HCl (psoralen) + UVA (320–400 nm) | FFP, PC | 4–7 log10 steps |
| MIRASOL PRT system | riboflavin (vitamin B2) + (UA) UVB (265–370) | FFP, PC, RBC, WB | 4–6 log10 steps |
| THERAFLEX UV-platelet system | None UVC irradiation (254 nm) only | PC | 4–6 log10 steps |
| S-303 PRT system | S-303 (psoralen), glutathione activation upon pH shift | RBC, WB | 4–6 log10 steps |
| TMB Plasma system | methylene blue + visible light (590 nm) | FFP | ≥6 log10 steps |
Legend
PRT: pathogen-reduction technology; UV: ultraviolet light; PLT: platelet; FFP: fresh frozen plasma; PC: platelet concentrate; RBC: packed red blood cells; WB: whole blood.