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. 2012 Jul 6;23(9):2044–2057. doi: 10.1093/cercor/bhs188

Figure 2.

Figure 2.

Gene variants covarying with white matter tract integrity. Upper panel: Patients with schizophrenia and healthy controls analyzed together demonstrating a significant LV of gene variants that reliably predict white matter tract integrity (i.e., SE to salience ratio >2.0). White matter tract integrity reliably correlated as part of this significant LV is strongly colored (schizophrenia: Upper stack, yellow; healthy controls: Lower stack, purple): SV = 1.6, CC = 44%, P < 0.001. Gene variants in MAG and CNP reliably predicted FA of all white matter tracts except for right arcuate and cingulum in schizophrenia patients and bilateral UF, right arcuate and splenium of the corpus callosum in controls. Lower panels: Patients (left) and controls (right) analyzed separately. Significant LVs were found in each group where gene variants reliably predict white matter tract integrity (i.e., SE to salience ratio >2.0). White matter tract integrity reliably correlated with genetic predictors is strongly colored. In patients (yellow), the MAG rs756796 SNP predicted integrity of all white matter tracts examined, except for right CB: SV = 1.4, CC = 64%, P = 0.03, while in healthy controls (purple), MAG, CNP, and OLIG2 SNPs predicted integrity at all white matter tracts except left and right UF: SV = 1.3, CC = 67%, P = 0.01.