Figure 4.

Integrity of white matter tracts mediating relationships between gene variants and cognitive performance. Upper panel: Schizophrenia patients and healthy controls analyzed together. A significant LV was found where microstructural integrity of white matter tracts reliably mediate relationships between gene variants and cognitive task performance (i.e., SE to salience ratio of >2.0). Gene variants, white matter tracts, and cognitive tasks reliably correlated (95% confidence interval) are strongly colored: SV = 2.6, CC = 43%, P < 0.001. Here, nearly all white matter tracts in schizophrenia patients: Upper stack, yellow, and right and left ILF in healthy controls: Lower stack, purple, mediated the relationship of MAG and CNP SNPs with cognitive performance on coding, letter cancellation task, and the executive interview. Lower panels: Schizophrenia patients and healthy controls analyzed separately. A significant LV was found in schizophrenia patients (yellow), where microstructural integrity of all white matter tracts mediated the relationships between the MAG rs756796 SNP with performance on visuospatial and visuomotor speed tasks, and executive function: SV = 2.3, CC = 63%, P = 0.05. In healthy controls, bilateral ILF and IFOF, left AF and UF, and splenium of CC mediated effects of MAG, CNP, and OLIG2 SNPs on coding and trials BA ratio scores: SV = 2.0, CC = 53%, P = 0.02.