Table 2.
Regression analyses of the predictors of the hydroxybupropion/bupropion ratio, hydroxybupropion levels, and bupropion levels.
| Predictors | OH-BUP/BUP ratio R2=0.055 P=0.02 |
OH-BUP levels (ng/ml) R2=0.11 P=0.001 |
BUP levels (ng/ml) R2=0.03 P=0.21 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| B | β | 95% CI | P | B | β | 95% CI | P | B | β | 95% CI | P | |
| Bupropion adherent only (n=154) | ||||||||||||
| CYP2B6 groups (Intermediate vs. normal) | −16.9 | −0.20 | −31.8 to −1.9 | 0.027 | −162.3 | −0.17 | −325.8 to 1.3 | 0.052 | 13.5 | 0.17 | −0.3 to 27.4 | 0.056 |
| CYP2B6 groups (Slow vs. normal) | −24.3 | −0.23 | −42.7 to −6.0 | 0.010 | −333.6 | −0.28 | −534.3 to −132.9 | 0.001 | 9.0 | 0.09 | −8.0 to 26.0 | 0.297 |
| Age (Increasing) | 0.2 | 0.04 | −0.4 to 0.8 | 0.580 | 9.1 | 0.22 | 2.7 to 15.6 | 0.006 | 0.2 | 0.07 | −0.3 to 0.8 | 0.366 |
B is the unstandardized coefficient. β is the standardized coefficient (i.e. standardized to a variance of 1). The B and β provided refers to the variables listed in parentheses beside each categorical predictor. OH-BUP=hydroxybupropion. Total n=154 (slow: n=31, intermediate: n=64, normal: n=58).