Table 3.

Model^* results for progression for individuals with normal cognition or MCI at baseline

	Always depressed versus never depressed**			p-value
	Rate Ratio (95% CI)
From Normal at Baseline to MCI***
Always depressed during follow-up	2.35	1.86	2.96	<0.0001
Depressed at 1st visit but later not depressed	1.41	1.01	1.95	0.04
Intermittent depression over follow-up	2.22	1.86	2.65	<0.0001
Prior history of depression	1.00	0.81	1.23	0.99
Antidepressant****
SSRI	1.22	0.98	1.51	0.08
Non-selective/Other	1.17	0.93	1.48	0.17
From MCI at baseline to AD***
Always depressed during follow-up	1.21	1.00	1.46	0.06
Depressed after 1st visit but later not depressed	0.86	0.64	1.16	0.33
Intermittent depression over follow-up	1.15	0.97	1.37	0.11
Prior history of depression	0.96	1.04	0.89	0.66
Antidepressant****
SSRI	1.38	1.17	1.63	0.0001
Non-selective/other	1.25	1.03	1.52	0.02

^*All models adjusted for age, gender, race, education, history of stroke/transient ischemic attack (TIA), history of diabetes, four cognitive tests (MMSE, logical memory, category fluency, WAIS), and functional activity (FAQ). Data for missing values imputed.

^**depression defined as either current or in the last 2 years.

^***5,607 (883 transitioned) individuals in analysis from normal to worse, 2,500 (856 transitioned) individuals in analysis from MCI to AD.

^****Drugs are time-dependent, considered at time of failure of each index case.