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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Sep 7;22(21):6656–6660. doi: 10.1016/j.bmcl.2012.08.105

Table 4. ADMET properties for ML221.

Compound characteristic
Aqueous solubility pH 7.4 25.5 μg/mL
Plasma protein binding (mouse) 99.1%
Permeability (PAMPA) pH 7.4 271.0 × 10−6cm/s
Hepatic microsome Stability (mouse) 4.9%
Plasma stability 42.2%
Cytotoxicity >50 μM