Table 4. ADMET properties for ML221.
| Compound characteristic | |
|---|---|
| Aqueous solubility pH 7.4 | 25.5 μg/mL |
| Plasma protein binding (mouse) | 99.1% |
| Permeability (PAMPA) pH 7.4 | 271.0 × 10−6cm/s |
| Hepatic microsome Stability (mouse) | 4.9% |
| Plasma stability | 42.2% |
| Cytotoxicity | >50 μM |