Table 2.
Results of Meta-Analysis of Previously Reported Association Results From the US-Based Study and the Australian Study
|
SNP |
Gene |
Minor Allele |
OR US Study |
P
Value US Study |
Meta
P
Value |
| rs4839200* | KCND3 | A | 1.79 | 3.90 × 10−4 | 1.61 × 10−7 |
| rs12407427* | KIF26B | T | 1.79 | 4.10 × 10−5 | 2.69 × 10−4 |
| rs4954218† | RAB3GAP1 | G | 0.62 | 1.60 × 10−7 | 9.26 × 10−9 |
| rs6430585 | UBXD2 | A | 1.39 | 0.002 | 4.96 × 10−4 |
| rs3749350 | LRRN1 | T | 1.39 | 1.40 × 10−4 | N/A |
| rs6442925 | BHLHB2 | T | 1.56 | 9.60 × 10−5 | 9.60 × 10−4 |
| rs6792542 | 3q26.2 | C | 1.31 | 0.003 | 0.014 |
| rs2659546 | PPP3CA | A | 1.63 | 0.021 | 0.090 |
| rs757219 | IMMPL2 | C | 1.36 | 0.006 | 6.77 × 10−6 |
| rs214884 | IMMPL2 | G | 1.44 | 0.007 | 1.42 × 10−5 |
| rs1978238* | 12p13.3 | C | 0.64 | 3.40 × 10−6 | 3.35 × 10−5 |
| rs1328083 | 13q33.3 | G | 1.31 | 0.0110 | 1.24 × 10−4 |
| rs1328089* | 13q33.3 | C | 1.61 | 8.8 × 10−4 | 3.47 × 10−5 |
| rs8111998 | 19p12 | T | 1.71 | 4.90 × 10−4 | 9.60 × 10−4 |
| rs1428642 | BIRC8 | A | 0.84 | 0.014 | N/A |
The previously reported OR and P values from the US study also are given. N/A, meta-analysis not conducted due to opposite direction of effect at these SNPs.
*
Meta-analysis includes P value from the US discovery cohort and Australian sample only. US replication cohort data not available for these SNPs.
†
Genome-wide significant results.