Regulation of Aqp0a by phosphorylation is required for lens clarity. (a) MIPfunS231A and D do not respond to calcium in the Xenopus oocyte swelling assay. Neither can rescue cataract caused by Aqp0a-MO ([b, c], respectively), while both can rescue cataract caused by Aqp0b-MO ([d, e], respectively). Asterisks indicate P is less than 0.025 between indicated group and MO-alone group.