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Gating of Aqp0a is required for lens clarity. (a) MIPfunY75G does not respond to calcium in the Xenopus oocyte swelling assay. The Y75G variant cannot rescue cataract caused by Aqp0a-MO (b), but can rescue cataract caused by Aqp0b-MO (c). Asterisks indicate P is less than 0.025 between indicated group and MO-alone group.
