Table 3.
Clinicopathological features in metastatic colorectal cancer patients according to EGFR expression
| Parameter | High expression of EGFR (TS > 4) |
Low expression of EGFR (TS ≤ 4) |
P-value |
|---|---|---|---|
| Age (years) | |||
| ≤75 | 45 | 114 | 0.6326 |
| >75 | 7 | 14 | |
| Gender | |||
| Male | 25 | 61 | 0.9233 |
| Female | 27 | 68 | |
| Histologic differentiation | |||
| Well/moderate | 12 | 18 | 0.1353 |
| Poorly/unknown | 40 | 111 | |
| Primary tumor | |||
| Colon | 22 | 45 | 0.3493 |
| Sigmoid/rectum | 30 | 84 | |
| Performance status (World Health Organization) | |||
| 0–1 | 46 | 125 | 0.0589* |
| 2 | 6 | 4 | |
| Performance status (Karnofsky) | |||
| ≤80 | 6 | 5 | 0.1077* |
| >80 | 46 | 124 | |
| Invasive extent | |||
| Tx–2 | 5 | 18 | 0.5848* |
| T3–4 | 47 | 111 | |
| Nodal status | |||
| Negative | 8 | 19 | 0.9057 |
| Positive | 44 | 110 | |
| Sites of metastases | |||
| Liver | 33 | 83 | 0.9111 |
| Other | 19 | 46 | |
| Number of organs involved | |||
| 1 | 23 | 46 | 0.2826 |
| ≥2 | 29 | 83 | |
| Pretreatment carcinoembryonic antigen level (ng/mL) | |||
| >5 | 25 | 55 | 0.5048 |
| ≤5 | 27 | 74 | |
Note:
*
P-values calculated by the Chi-square test with Yates correction.
Abbreviations: EGFR, epidermal growth factor receptor; TS, total score.