Table 5.
Univariate and multivariate analysis of overall survival
| Covariate | Univariate analysis
|
Multivariate analysis
|
||||||
|---|---|---|---|---|---|---|---|---|
| HR | −95% CI | +95% CI | P-value | HR | −95% CI | +95% CI | P-value | |
| Sites of metastases | ||||||||
| Liver vs other | 1.57 | 1.03 | 2.40 | 0.0358 | 2.13 | 1.33 | 3.40 | 0.0017 |
| Primary tumor | ||||||||
| Colon vs sigmoid/rectum | 2.05 | 1.38 | 3.06 | 0.0004 | 2.19 | 1.45 | 3.32 | 0.0002 |
| Performance status (World Health Organization) | ||||||||
| 2 vs 0–1 | 3.76 | 1.93 | 7.33 | <0.0001 | 6.25 | 2.97 | 13.16 | <0.0001 |
| Pretreatment carcinoembryonic level (ng/mL) | ||||||||
| >5 vs ≤5 | 2.18 | 1.65 | 2.88 | <0.0001 | 2.04 | 1.52 | 2.73 | <0.0001 |
| Proportion score | ||||||||
| >3 vs ≤3 | 1.83 | 1.19 | 2.84 | 0.0063 | 1.62 | 1.03 | 2.53 | 0.0359 |
| Age (years) | ||||||||
| >75 vs ≤75 | 2.23 | 1.30 | 3.82 | 0.0035 | – | – | – | NS |
| Performance status (Karnofsky) | ||||||||
| ≤80 vs >80 | 2.70 | 1.44 | 5.07 | 0.0019 | – | – | – | NS |
| Total score | ||||||||
| >4 vs ≤4 | 1.53 | 1.02 | 2.30 | 0.0382 | – | – | – | NS |
Abbreviations: CI, confidence interval; HR, hazard ratio; NS, not significant.