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. Author manuscript; available in PMC: 2013 Jul 31.
Published in final edited form as: Eur J Immunol. 2010 Mar;40(3):649–653. doi: 10.1002/eji.200940191

Figure 2.

Figure 2

Excessive IL-1β production from NLRP3 mutated APCs induces T cell production of IL-17 and consequently neutrophilic inflammation in tissues. Antigen presenting cells (APCs) from NLRP3 mutated mice secrete elevated amounts of IL-1β due to hyperactive inflammasome activation, possibly triggered by minor trauma. Subsequently, IL-1β enhances IL-17 production from helper T cells. The Th17 induces neutrophil infiltration and results in tissue damage. Positive feed back also operates since neutrophils also produce IL-1β due to NLRP3 inflammasome hyper activation and thus amplify the inflammation.