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. Author manuscript; available in PMC: 2014 May 15.
Published in final edited form as: J Immunol. 2013 Apr 15;190(10):4982–4990. doi: 10.4049/jimmunol.1202986

FIGURE 2.

FIGURE 2

Lupus-associated dermatitis in MRL- Faslpr mice is not significantly affected by absence of NA-TLRs. (A) Incidence of dermatitis in mice over time (9–11 mice/group). (B) Surface area of skin lesions at 7 mo (8–18 mice/group). (C) Blinded scores of immune infiltration, basement membrane changes, and follicle loss in skin sections (9–15 mice/ group). (D) Representative H&E sections of skin showing similar epidermal thickening and hyperkeratosis in 7- to 8-mo-old WT/Het and 3d skin compared with B6. IgA anti-Dsg3 levels (E) and IgG3 cryoglobulin levels (F) from 6-mo-old mice. Data representative of three independent experiments. +++p < 0.001.