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Structural components of HBV (left) and open reading frames (ORF) for encoding proteins in the covalently closed form of HBV DNA. The HBV core contains besides the HBV genome the HBV polymerase with the primase (pr) and the reverse transcriptase (RT) domain and the cellular protein kinase C alpha (PKC) [24]. Note the two start codons in the PreC/core ORF and the three start codons in the HBs ORF.
