1
|
AcpP
|
Acyl carrier protein
|
It shuttles the intermediates between the enzymes of type II fatty acid synthase system
|
[31]
|
2
|
FbpA
|
Secreted antigen 85-A
|
It participates in cell wall biosynthesis, and interacts with the host macrophage as fibronectin-binding protein. It is also involved in establishment and maintenance of a persistent tuberculosis infection
|
[32,33]
|
3
|
GroES
|
Co-chaperonin
|
It is a dominant immunogenic protein
|
[34]
|
4
|
DnaK
|
Molecular chaperone
|
It is highly antigenic and act as co-repressors for heat shock protein transcriptional repressor (hspR)
|
[35]
|
5
|
Tpx
|
Thiol peroxidase
|
It protects M. tuberculosis against oxidative and nitrosative stress
|
[36]
|
6
|
RpiL
|
50S ribosomal protein L7/L12
|
It is involved in interaction with translation factors
|
[37]
|
7
|
BfrA
|
Bacterioferritin
|
It is an intracellular iron storage protein, which protects Mycobacterium from oxidative stress mediated by excess iron
|
[38]
|
8
|
SahH
|
S-adenosyl-L-homocysteine hydrolase
|
It is a ubiquitous enzyme that plays a central role in methylation-based processes by maintaining the intracellular balance between S-adenosylhomocysteine (SAH) and S-adenosylmethionine
|
[39]
|
9
|
TrxC
|
Thioredoxin
|
It is involved in redox homeostasis and uses it to protect the pathoen against the oxidative intermediates generated by the macrophages
|
[40]
|
10
|
FixB
|
Electron transfer flavoprotein subunit alpha
|
It is electron transfer flavoprotein subunit alpha, in some bacteria it functions as nitrogen fixing agent but its function in M .tuberculosis is not clear
|
[41]
|
11
|
PepA
|
Serine protease
|
It is a serine protease associated with cell membrane, which stimulates peripheral blood mononuclear cells from healthy PPD donors to proliferate and secrete gamma interferon
|
[42]
|
12
|
Wag31
|
Hypothetical protein
|
It is a cell division initiation protein involved in regulation of genes including virulence factors and antigens
|
[43]
|
13
|
Mpt64
|
Hypothetical protein
|
It is an immunogenic protein which elicits delayed type hypersensitivity skin response
|
[44]
|
14
|
Apa
|
Alanine and proline rich secreted protein
|
It is a cell surface glycoprotein which binds to host lectins and cheat the innate immune system
|
[45]
|
15
|
LprG
|
Lipoprotein LprG
|
It plays a role in M. tuberculosis infection by inducing increased suppression of the immune response due to elevated nitric oxide production
|
[46]
|
16
|
Rv1893
|
Hypothetical protein
|
Function unknown
|
[47]
|
17
|
Rv1855c
|
Oxidoreductase
|
Probable monooxygenase
|
[48]
|
18 |
Gap |
Glyceraldehyde-3-phosphate dehydrogenase |
It has glyceraldehyde-3-phosphate dehydrogenase activity |
[49] |