Table 3.
Microbiologic features of non-RDRio and RDRio pulmonary tuberculosis patients
| Non-RDRio | RDRio | |||||
|---|---|---|---|---|---|---|
| Total n |
Positive n (%) |
Total n |
Positive n (%) |
P value | OR (95%CI) | |
| AFB smear on admission | ||||||
| Spontaneous sputum | 140 | 127 (90.7) | 56 | 50 (89.3) | 0.76 | 0.85 (0.31–2.37) |
| Induced sputum or BAL | 60 | 34 (57.6) | 16 | 5 (31.25) | 0.09 | 0.33 (0.10–1.08) |
| Bacillary load on admission* | 196† | 72 | ||||
| 1–19 colonies | 19 (9.7) | 10 (13.9) | 0.33 | 1.5 (0.66–3.4) | ||
| 1+ | 77 (39.3) | 23 (31.9) | 0.27 | 0.73 (0.41–1.3) | ||
| 2+ | 52 (26.5) | 14 (19.4) | 0.23 | 0.67 (0.34–1.3) | ||
| 3+ | 48 (24.5) | 25 (34.7) | 0.09 | 1.6 (0.91–2.9) | ||
| Median time to growth detection, days | 200 | (21.0) | 72 | (21.5) | 0.58 | — |
| Culture-positive at 2 months of treatment | 57 | 14 (24.6) | 20 | 5 (25.0) | 1.0 | 1.02 (0.32–3.33) |
| Drug resistance‡ | ||||||
| RMP | 193 | 7 (3.6) | 70 | 1 (1.4) | 0.69 | 0.39 (0.05–3.2) |
| INH | 191 | 20 (10.5) | 70 | 3 (4.3) | 0.14 | 0.38 (0.11–1.3) |
| Ethambutol | 188 | 5 (2.7) | 69 | 1 (1.4) | 1.0 | 0.54 (0.06–4.70) |
| Streptomycin | 193 | 17 (8.8) | 70 | 6 (8.6) | 0.95 | 0.97 (0.37–2.6) |
| Ethionamide | 176 | 3 (1.7) | 61 | 0 | 0.57 | 0.40 (0.02–7.9) |
| MDR-TB§ | 170 | 6 (0.3) | 61 | 1 (0.04) | 0.46 | 0.46 (0.05–3.86) |
*
1+ = 20–100 colonies; 2+ = 100–200 colonies; 3+ ≥201 colonies.
†
4 cultures performed using Mycobacteria Growth Indicator Tube 960 were excluded.
‡
Pyrazinamide susceptibility testing was not performed.
§
Resistance to both INH and RMP.
OR = odds ratio; CI = confidence interval; AFB = acid-fast bacilli; BAL = bronchoalveolar lavage; RMP = rifampin; INH = isoniazid; MDR-TB = multidrug-resistant tuberculosis.