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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Gastroenterology. 2013 Jun;144(6):1210–1219. doi: 10.1053/j.gastro.2012.11.037

Figure 1.

Figure 1

Identification of activated PaSCs in the stroma of PDAC and PanIN. (A) Immuno-histochemistry for α–smooth muscle actin (αSMA) (brown) and procollagen α1(I) (blue) on human PDAC tissues indicates that active PaSCs are the main source of collagens in the tumor stroma. Low- (A) and high- (B) power views of a representative section of human pancreatic cancer tissue. (C,D) Immunohis-tochemical staining for αSMA (brown) reveals abundant activated PaSCs surrounding Pan-INs in human pancreas. (E, F) Sirius red (red; E) and αSMA (brown; F) staining on pancreatic tissue from a GEM model (KrasLSL-G12D/+; Pdxcre/+) illus- trates the abundance of collagens and activated PaSCs surrounding PanINs.