Table 2.
In vitro minimum inhibitory concentration of antimicrobial peptide dendrimer against gram-positive and gram-negative bacteria82
| Microbe | Relevant features | MIC (μg mL-1) |
|---|---|---|
| Escherichia coli ATTCC 25922 | Reference strain | 8 |
| Escherichia coli W99FI0077 | FQ, ESC (ESBL/SHV type) | 8 |
| Escherichia coli W03BG0025 | FQ, AG, ESC (ESBL/CTX-M-15) | 8 |
| Escherichia coli W03NO0013 | FQ, ESC (ESBL/CTX-M-1) | 8 |
| Pseudomonas aeruginosa ATCC 27853 | Reference strain | 4 |
| Pseudomonas aeruginosa 885149 | FQ, AG, ESC, CP (MBL/IMP-13) | 8 |
| Pseudomonas aeruginosa 891 | FQ, AG, ESC, CP (MBL/VIM-2) | 8 |
| Pseudomonas aeruginosa VA463/98 | FQ, AG, ESC (ESBL/PER-1) | 4 |
| Klebsiella pneumoniae W99FI0057 | ESC (ESBL/SHV type) | 4 |
| Klebsiella pneumoniae W03NO0078 | ESC (ESBL/CTX-M-1) | 16 |
| Klebsiella pneumoniae W03BG0019 | AG, ESC (ESBL/CTX-M-15) | 8 |
| Klebsiella oxytoca W99FI00049 | ESC (ESBL/SHV-12) | 64 |
| Proteus mirabilis W99FI0089 | FQ | >128 |
| Proteus mirabilis W03VA1144 | FQ, AG, ESC (ESBL/PER-1) | 64 |
| Enterobacter aerogenes W03BG0067 | AG, ESC (ESBL/SHV-5) | 8 |
| Enterobacter cloacae W03AN0041 | ESC (ESBL/SHV-12) | 4 |
| Morganella morganii W03VA1342 | FQ, ESC (ESBL/CTX-M-1) | >128 |
| Acinetobacter baumannii AB1MG | FQ, AG, ESC (ESBL/TEM-92) | 16 |
| Acinetobacter baumannii AB7MG | FQ, AG, ESC | 32 |
| Citrobacter freundii W99FI00007 | ESC (ESBL/SHV-12) | 16 |
| Chryseobacterium meningosepticum CCUG4310 | Reference strain | >128 |
| Burkholderia cepacia SMC71 | FQ, AG, ESC | 64 |
| Serratia marcescens W99FI0111 | FQ, AG, ESC (ESBL/SHV-5) | >128 |
| Stenotrophomonas maltophilia PT4/99 | Wild-type profile | >128 |
| Providencia stuartii W03FI0001 | AG, ESC (ESBL/PER-1) | >128 |
| Staphylococcus aureus ATCC 25923 | Reference strain | >128 |
| Staphylococcus aureus MIU-68A | MS | 128 |
Relevant resistance phenotypes and resistance mechanisms are indicated by FQ (resistance to fluoroquinolines), AG (resistance to aminoglycosides), ESC (resistance to extended-spectrum cephalosporins), CP (resistance to carbapenems), ESBL (extended-spectrum β-lactamase), MBL (metallo-β-lactamase), and MS (methicillin susceptible).