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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Curr Opin Cell Biol. 2013 Jun 7;25(4):506–511. doi: 10.1016/j.ceb.2013.04.011

Figure 1.

Figure 1

Summary of factors that regulate the assembly or disassembly of cilia. Upon cilia formation and elongation (red arrow), IFT components, MARK4, and TTBK2 are recruited to the basal body, whereas ciliary inhibitors, such as CP110, Cep97, Kif24, and Trichoplein are displaced. Ciliary elongation is directly promoted by the abundance and motility rate of the IFT-B complex and the availability of soluble tubulin as axonemal precursors. Several structural modifications also occur during cilia formation; the distal and sub-distal appendages become transition fibers and basal feet, respectively, and the formation of transition zones and ciliary pockets for their role in ciliary trafficking. Conversely, during ciliary disassembly (black arrow), CP110, Cep97, Kif24, and Trichoplein are expressed at the basal body. Additionally, several factors, including components involved in the IFT-A complex, axonemal deacetylation, axonemal microtubule depolymerization, and actin polymerization negatively regulate cilium assembly.

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