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. Author manuscript; available in PMC: 2014 Sep 10.
Published in final edited form as: Gene. 2013 May 25;526(2):187–194. doi: 10.1016/j.gene.2013.05.018

Figure 5. Model explaining the regulatory role of hnRNP poly(ADP-ribosyl)ation in eye pattern development.

Figure 5

(A) In a temporal- or spatial-specific way, protein poly(ADP-ribosyl)ation is reversed by PARG activity. Therefore, HRP proteins are not poly(ADP-ribosyl)ated and will bind to their target pre-mRNAs for RNA processing or translational control, which further regulates developmental patterns. (B) Once PARG activity is downregulated in different tissues or developmental stages, HRP proteins are poly(ADP-ribosyl)ated, which inhibits Hrps from binding to pre-mRNA. Therefore, the pre-mRNA bound by Hrps are not processed or translated, and developmental patterns are changed. (C) Mutating HRP proteins blocks pre-mRNA processing or translation.