Table 1.
Genetic prediction of incident T2DM in prospective studies
| Study | Subjects (n) | SNPs (n) | AUC-ROC | ||
|---|---|---|---|---|---|
| Genetic model | Clinical model | Both models | |||
| MPP+Botnia Study (14) | 18,831 | 11 | 0.62 | 0.74 | 0.75* |
| FOS (15) | 2.377 | 18 | 0.58 | 0.9 | 0.901* |
| DESIR (16) | 3,877 | 3 | 0.56 | nr | nr |
| Rotterdam Study (17) | 6,544 | 18 | 0.6 | 0.66 | 0.68* |
| Whitehall II Study (18) | 5,535 | 20 | 0.55 | 0.78 | 0.78 |
| FOS (12) | 3,471 | 40 | 0.6 | 0.903 | 0.906* |
MPP: Malmoe Preventive Program
FOS: Framingham Offspring Study
DESIR: Data from the Epidemiological Study on the Insulin Resistance Syndrome
AUC-ROC: area under the receiver-operating-characteristic curve
nr: not reported, though assessed
*
= significantly different as compared to clinical model