Table 4.
Relation of five baseline 3D bone shape vectors to risk of incident radiographic knee OA in the whole sample and among knees that were KL=0 at baseline
| 3D bone shape vector tertiles* | Adjusted† OR (95% CI) | |||
|---|---|---|---|---|
| Relation of baseline 3D bone shape to incident radiographic OA In the whole sample | Relation of baseline 3D bone shape to incident radiographic OA Among knees that were KL=0 at baseline | |||
| Incident radiographic knee OA, irrespective of time of OA onset | Incident radiographic knee OA, occurring 24-48 months later | Incident radiographic knee OA, irrespective of time of OA onset | Incident radiographic knee OA, occurring 24-48 months later | |
| Whole joint (femur, tibia, patella) | ||||
| Highest | 2.5 (1.5-4.1) | 3.0 (1.5-6.0) | 6.2 (2.1-18.4) | 6.6 (1.8-24.9) |
| Middle | 1.8 (1.1-2.9) | 2.6 (1.3-5.1) | 2.0 (0.8-5.4) | 2.2 (0.7-7.0) |
| Lowest | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| P for linear trend | p=0.0005 | p=0.003 | p=0.001 | p=0.005 |
| Per SD unit towards OA | 1.5 (1.2-1.8) p=0.0003 | 1.6 (1.2-2.1) p=0.001 | 2.0 (1.3-3.1) p=0.0009 | 2.5 (1.4-4.6) p=0.002 |
| Tibiofemoral joint (femur, tibia) | ||||
| Highest | 1.8 (1.1-2.9) | 2.4 (1.2-4.7) | 4.2 (1.4-12.3) | 6.0 (1.6-22.3) |
| Middle | 1.6 (1.0-2.6) | 2.3 (1.2-4.5) | 2.8 (1.0-7.3) | 3.1 (1.0-9.6) |
| Lowest | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| P for linear trend | p=0.03 | p=0.01 | p=0.008 | p=0.006 |
| Per SD unit towards OA | 1.3 (1.1-1.6) p=0.003 | 1.5 (1.2-2.0) p=0.002 | 1.7 (1.2-2.5) p=0.004 | 2.4 (1.4-4.1) p=0.002 |
| Femur only | ||||
| Highest | 2.0 (1.2-3.3) | 3.5 (1.7-6.9) | 3.9 (1.4-10.5) | 4.8 (1.5-15.6) |
| Middle | 1.8 (1.1-2.9) | 2.8 (1.4-5.5) | 1.8 (0.7-4.7) | 1.5 (0.5-4.8) |
| Lowest | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 |
| P for linear trend | p=0.006 | p=0.0004 | p=0.009 | p=0.006 |
| Per SD unit towards OA | 1.4 (1.1-1.7) p=0.002 | 1.7 (1.3-2.3) p=0.0002 | 1.6 (1.1-2.3) p=0.007 | 2.2 (1.3-5.5) p=0.002 |
| Tibia only | ||||
| Highest | 1.2 (0.8-1.9) | 1.4 (0.7-2.6) | 2.6 (1.0-7.0) | 2.3 (0.7-7.2) |
| Middle | 1.0 (0.6-1.6) | 1.3 (0.7-2.4) | 1.0 (0.8-4.7) | 1.9 (0.7-5.3) |
| Lowest | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| P for linear trend | p=0.4 | p=0.3 | p=0.04 | p=0.1 |
| Per SD unit towards OA | 1.1 (0.9-1.4) p=0.2 | 1.2 (0.9-1.5) p=0.2 | 1.5 (1.0-2.3) p=0.06 | 1.5 (0.9-2.4) p=0.1 |
| Patella only | ||||
| Highest | 1.9 (1.1-3.0) | 1.6 (0.8-3.2) | 3.0 (1.1-8.3) | 3.7 (1.0-14.0) |
| Middle | 1.4 (0.9-2.3) | 1.5 (0.8-2.8) | 1.7 (0.7-4.2) | 1.3 (0.4-4.0) |
| Lowest | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | p=0.06 |
| P for linear trend | p=0.01 | p=0.2 | p=0.04 | |
| Per SD unit towards OA | 1.3 (1.1-1.6) p=0.01 | 1.2 (0.9-1.6) p=0.1 | 1.5 (1.0-2.2) p=0.07 | 1.5 (0.9-2.7) p=0.1 |
*
the vector range is -1 (mean non-OA shape) to +1 (mean OA shape); therefore lowest tertile is the referent group
†
adjusted for age, sex, BMI