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. 2013 Jul 22;14:493. doi: 10.1186/1471-2164-14-493

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Copyright © 2013 Smagulova et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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DSB repair in Gal4BD-Spo11 spermatocytes is incomplete. Chromosomal spreads from earlier (zygotene) and later (pachytene) stage spermatocytes were immunostained with antibodies to γH2AX (red) and SCP3 (green). Note the disappearance of γH2AX staining at homologously synapsed autosomes in later stage wild type and Spo11^Gal/Gal spermatocytes consistent with proper repair of DSBs. γH2AX persist in Spo11^Gal/- spermatocytes and on asynapsed chromosomes in Spo11^Gal/Gal spermatocytes. Sex body (white arrow) is evident in wild type, but not Gal4BD-Spo11 spermatocytes.