Table 1.
Metabolic and phenotypic evolution
| |
WT |
Ob/ob |
DKO |
||||
|---|---|---|---|---|---|---|---|
| At 12 w | Untreated | Food restriction | ACE-I | Untreated | Food restriction | ACE-I | |
| Body Weight(g) |
21.1±1.0 |
49.5±0.6* |
49.8±0.9* |
49.0±0.3* |
48.8±0.7* |
51.2±0.6* |
45.2±1.6* |
| Glycemia(mg/dL) |
56±2.0 |
159.3±18.5* |
166±13.7* |
155±14.5* |
155±10.2* |
156±8.8* |
160±12.9* |
| Total Chol(mg/dL) |
104±25 |
129±6£ |
131±6 |
116±6 |
977±45*+ |
958±77* |
735±90*£ |
| Triglycerides(mg/dL) |
115±15 |
53±2*£ |
53±2* |
69±3* |
585±66*+ |
618±75* |
455±69* |
| HDL(mg/dL) |
68±11 |
106±5*£ |
107±5* |
90±4* |
232±5*+ |
112±10*£ |
137±11*£ |
| LDL(mg/dL) |
16±11 |
13±2 |
14±2 |
12±3 |
/ |
/ |
308±228* |
| |
WT |
Ob/ob |
DKO |
||||
|
At 18 w |
|
Untreated |
Food restriction |
ACE-I |
Untreated |
Food restriction |
ACE-I |
| Body Weight(g) |
22.1±1.3 |
56.6±0.9*£ |
37.1±1.1*+ |
54.0±0.4* |
49.8±3.4*+ |
37.3±0.7*£ |
53.9±1.8* |
| Glycemia(mg/dL) |
72±4.5 |
134±18.9 |
176±19.9* |
119±9.1 |
142±13.4 |
158±19.8* |
191±24.3* |
| Total Chol(mg/dL) |
80±7 |
154±13* |
77±6+ |
140±10* |
579±145*+ |
794±59* |
527±63* |
| Triglycerides(mg/dL) |
75±6 |
81±2 |
74±5 |
70±2 |
334±80*+ |
331±38* |
171±19£ |
| HDL(mg/dL) |
62±6 |
123±9*£ |
67±7+ |
112±7* |
100±6*+ |
201±18*£ |
159±11*£ |
| LDL(mg/dL) |
4±2 |
15±4* |
/ |
16±3* |
277±100*+ |
519±35*£ |
334±50* |
| |
WT |
Ob/ob |
DKO |
||||
|
At 24 w |
|
Untreated |
Food restriction |
ACE-I |
Untreated |
Food restriction |
ACE-I |
| Body Weight(g) |
27.1±0.9 |
64.5±0.9* |
34.0±2.3*+ |
65.8±1.3* |
61.2±1.7* |
35.9±1.3*£ |
61.8±1.0* |
| Heart Weight(mg) |
164.4±9.6 |
196.1±9.3* |
136.4±2.8*+ |
178.7±4.0 |
184.2±10.0 |
132.7±3.0*£ |
161.2±4.0£ |
| HW/BW ratio(mg/g) |
6.2±0.5 |
3.1±0.1* |
4.3±0.3*+ |
2.7±0.1* |
3.1±0.1* |
3.8±0.2* |
2.6±0.1* |
| Glycemia(mg/dL) |
71±4,5 |
166±11.8* |
142±12.1* |
84±5.0+ |
141±28.6* |
153±18.2* |
124±8.7* |
| Total Chol(mg/dL) |
93±17 |
139±10 |
74±8 |
145±10 |
576±78*+ |
816±74*£ |
634±55* |
| Triglycerides(mg/dL) |
68±9 |
68±3 |
69±5 |
76±4 |
210±30*+ |
301±60* |
202±21* |
| HDL(mg/dL) |
73±9 |
97±6 |
66±8 |
100±2 |
183±15*+ |
232±21*£ |
192±4* |
| LDL(mg/dL) | 8±7 | 29±5 | / | 34±8 | 351±66*+ | 432±24* | 402±49* |
This table shows the metabolic and phenotypic evolution from 12 till 24 weeks of age of WT (N =13), untreated ob/ob (N =10), untreated DKO (N =13), food-restricted ob/ob (N =32), food-restricted DKO (N =19), ob/ob treated with ACE-I (N =14) and DKO treated with ACE-I (N =16).
* denotes p < 0.05 vs. WT, + p < 0.05 vs. untreated ob/ob and £ p < 0.05 vs. untreated DKO; HW heart weight, BW body weight, Total Chol total cholesterol, HDL high-density lipoprotein, LDL low-density lipoprotein and / = No data available.