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. Author manuscript; available in PMC: 2014 Aug 9.
Published in final edited form as: Neurosci Lett. 2013 May 28;549:57–62. doi: 10.1016/j.neulet.2013.05.034

Figure 3. Diapocynin corrects loss of motor coordination without affecting gross motor function.

Figure 3

Diapocynin was synthesized through the reaction of two apocynin monomers in the presence of ferrous sulfate and sodium persulfate (A). Purity of the isolated compound was confirmed by HPLC (B) and MS analysis (C). An apocynin standard was run in parallel to confirm purity of the diapocynin solution. At 16 mo, brains were formaldehyde fixed, sliced, and slices containing the nigral region were stained for TH (D-G). Images shown are representative with 4x magnification in insets. Total movement (H) and rearing (I) were assessed over 20 min in an open field using a photobeam system. Latency to fall from a Rotor-Rod apparatus was also measured (J). Data are the means ± s.d. *, p≤0.05 as determined by one-way ANOVA with Bonferroni post-hoc. Encircled numbers represent the number of animals in each group.