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Tumor burden correlates inversely with rituximab serum concentration and half-life. (A) Median serum rituximab half-life in the first treatment cycle for patients with high (n=8) and low (n=9) tumor burden (P=0.02 by Student’s t-test). (B) ALC (solid lines) and rituximab trough levels (dotted lines) over time in 2 representative patients.
